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The initiation of an SGLT2 inhibitor or a GLP-1 receptor agonist compared with a DPP-IV inhibitor was associated with lower CV events and death without increasing the overall incidence rate of severe safety outcomes, regardless of frailty status, Elisabetta Patorno, MD, DrPH , associate professor of medicine at Harvard Medical School and associate epidemiologist in the division of pharmacoepidemiology and pharmacoeconomics at Brigham and Womens Hospital, and colleagues wrote